BiologicalActivity
PotentandselectiveGPR171partialagonist(EC50=90nM;28%inhibitionofforskolinactivatedadenylylcyclaseactivityinrathypothalamicmemebranes).Exhibitsminimalbindingtoapanelof~70GPCRsand10otherreceptors(<22%ofrADIoliganddisplacedfromthetargetreceptors).Increasesneuronalactivityintheparaventricularnucleus.Increasesfoodintakeandbodyweightinmice.
TechnicalData
| M.Wt | 249.22 |
| Formula | C12H11NO5 |
| Storage | Storeat-20°C |
| Purity | ≥98%(HPLC) |
| CASNumber | 73912-52-4 |
| PubChemID | 773544 |
| InChIKey | NVOBVSWSDYFEMR-UHFFFAOYSA-N |
| Smiles | CC(C(NC1=CC(C(O)=O)=CC(C(O)=O)=C1)=O)=C |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 24.92 | 100 | |
| ethanol | 4.98 | 20mMwithgentlewarming |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight249.22.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 4.01mL | 20.06mL | 40.13mL |
| 5mM | 0.8mL | 4.01mL | 8.03mL |
| 10mM | 0.4mL | 2.01mL | 4.01mL |
| 50mM | 0.08mL | 0.4mL | 0.8mL |
MolarityCalculator
ReconstitutionCalculator
Thereconstitutioncalculatorallowsyoutoquicklycalculatethevolumeofareagenttoreconstituteyourvial.Simplyenterthemassofreagentandthetargetconcentrationandthecalculatorwilldeterminetherest.