BiologicalActivity
Potentthioredoxinreductase(TrxR)inhibitor(EC50=2.8nM,IC50=0.03and0.1μMinMCF-7cellsandHT-29cells,respectively).Highlystableinvivo;exhibitsnosignificantligandexchangewithalbumin.Inhibitstumorproliferationinvitroandinvivobyinducingcelldeath.Selectivelykillscancercells.
TechnicalData
| M.Wt | 596.43 |
| Formula | C25H20AuOPS |
| Storage | Storeat-20°C |
| Purity | ≥98%(HPLC) |
| CASNumber | 1527513-89-8 |
| PubChemID | 127021039 |
| InChIKey | DROLHVHTLXUINH-UHFFFAOYSA-O |
| Smiles | [Au].COC1=CC=C(C=C1)C#C.S1C=CC=C1P(C1=CC=CC=C1)C1=CC=CC=C1 |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 59.64 | 100 |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight596.43.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 1.68mL | 8.38mL | 16.77mL |
| 5mM | 0.34mL | 1.68mL | 3.35mL |
| 10mM | 0.17mL | 0.84mL | 1.68mL |
| 50mM | 0.03mL | 0.17mL | 0.34mL |
MolarityCalculator
ReconstitutionCalculator
Thereconstitutioncalculatorallowsyoutoquicklycalculatethevolumeofareagenttoreconstituteyourvial.Simplyenterthemassofreagentandthetargetconcentrationandthecalculatorwilldeterminetherest.