Tocris/BAG 956/3606/50/50 mg-免疫在线蚂蚁淘旗下平台

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商品详细Tocris/BAG 956/3606/50/50 mg

Tocris/BAG 956/3606/50/50 mg

商品编号： 3606/50

品牌： Tocris Bioscience

市场价： ¥19300.00

美元价： 11580.00

产地：美国(厂家直采)

公司：

产品分类：其它酶

公司分类： Other_enzymes

联系Q Q： 3392242852

电话号码： 4000-520-616

电子邮箱： info@ebiomall.com

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商品介绍

Description:DualPI3-kinaseandPDPK1(PDK1)inhibitor

ChemicalName:α,α,-Dimethyl-4-[2-methyl-8-[2-(3-pyridinyl)ethynyl]-1H-imidazo[4,5-c]quinolin-1-yl]-benzeneacetonitrile

Purity:≥99%(HPLC)

BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences

BiologicalActivity

DualPDPK1(PDK1)andclassIPI3-Kinhibitor(IC₅₀valuesare245,56,446,35and117nMforPDPK1andPI3-Kp110-α,-β,-δ,and-γrespectively).InhibitscellularAKTphosphorylationatThr308.Blockscellproliferation,causingarrestinG₁phaseofthecellcycle.Slowstumorprogressioninmousexenograftmodels.

CompoundLibraries

BAG956isalsoofferedaspartoftheTocriscreenPlus.FindoutmoreaboutcompoundlibrariesavailablefromTocris.

TechnicalData

M.Wt	427.5
Formula	C₂₈H₂₁N₅
Storage	StoreatRT
Purity	≥99%(HPLC)
CASNumber	853910-02-8
PubChemID	24882589
InChIKey	GVPAGJWVBUZHNQ-UHFFFAOYSA-N
Smiles	CC3=NC1=C(N3C4=CC=C(C(C)(C#N)C)C=C4)C2=C(C=CC(C#CC5=CN=CC=C5)=C2)N=C1

Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.

AllTocrisproductsareintendedforlaboratoryresearchuseonly.

SolubilityData

	Solvent	MaxConc.mg/mL	MaxConc.mM
Solubility
	DMSO	17.1	40
	ethanol	8.55	20

PreparingStockSolutions

Thefollowingdataisbasedontheproductmolecularweight427.5.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.

Concentration/SolventVolume/Mass	1mg	5mg	10mg
1mM	2.34mL	11.7mL	23.39mL
5mM	0.47mL	2.34mL	4.68mL
10mM	0.23mL	1.17mL	2.34mL
50mM	0.05mL	0.23mL	0.47mL

ProductDatasheets

CertificateofAnalysis/ProductDatasheet

SafetyDatasheet

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BiologicalActivity

CompoundLibraries

TechnicalData

SolubilityData

PreparingStockSolutions

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ProductDatasheets