BiologicalActivity
L-typeCa2+channelactivator(EC50=17.3nM).Haspositiveinotropic,vasoconstrictiveandbehavioraleffectsinvivo.Separateenantiomers(R)-(+)-BayK8644and(S)-(-)-BayK8644alsoavailable(Cat.Nos.1545and1546respectively).IncombinationwithBIX-01294(Cat.No.3364),helpsgenerateinducedpluripotentstemcells(iPSCs)frommouseembryonicfibroblasts(MEFs).Inhibitsautophagy.
CompoundLibraries
(±)-BayK8644isalsoofferedaspartoftheTocriscreenStemCellToolbox.FindoutmoreaboutcompoundlibrariesavailablefromTocris.
TechnicalData
| M.Wt | 356.3 |
| Formula | C16H15F3N2O4 |
| Storage | Storeat+4°C |
| Purity | ≥99%(HPLC) |
| CASNumber | 71145-03-4 |
| PubChemID | 2303 |
| InChIKey | ZFLWDHHVRRZMEI-UHFFFAOYSA-N |
| Smiles | COC(=O)C1=C(C)NC(C)=C(C1C1=CC=CC=C1C(F)(F)F)[N+]([O-])=O |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 35.63 | 100 | |
| ethanol | 35.63 | 100 |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight356.3.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 2.81mL | 14.03mL | 28.07mL |
| 5mM | 0.56mL | 2.81mL | 5.61mL |
| 10mM | 0.28mL | 1.4mL | 2.81mL |
| 50mM | 0.06mL | 0.28mL | 0.56mL |
MolarityCalculator
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DilutionCalculator
ProductDatasheets
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