BiologicalActivity
Voltage-independent,selectiveCFTRchloridechannelblocker(Ki=300nM)thatalterschannelgating.BlocksintestinalfluidsecretioninducedbycholeratoxinandEscherichiacoliandsuppressescystgrowthinanimalmodelsofpolycystickidneydisease.Orallyactive.Inhibitsmitochondrialrespirationandincreasesreactiveoxygenspecies(ROS)productionindependentlyofCFTRinseveralcelllines.
CompoundLibraries
CFTRinh172isalsoofferedaspartoftheTocriscreenPlus.FindoutmoreaboutcompoundlibrariesavailablefromTocris.
TechnicalData
| M.Wt | 409.4 |
| Formula | C18H10F3NO3S2 |
| Storage | Storeat+4°C |
| Purity | ≥98%(HPLC) |
| CASNumber | 307510-92-5 |
| PubChemID | 1554210 |
| InChIKey | JIMHYXZZCWVCMI-RIYZIHGNSA-N |
| Smiles | O=C(N(C3=CC=CC(C(F)(F)F)=C3)C(S2)=S)C2=C/C1=CC=C(C(O)=O)C=C1 |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 40.94 | 100 |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight409.4.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 2.44mL | 12.21mL | 24.43mL |
| 5mM | 0.49mL | 2.44mL | 4.89mL |
| 10mM | 0.24mL | 1.22mL | 2.44mL |
| 50mM | 0.05mL | 0.24mL | 0.49mL |
MolarityCalculator
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ProductDatasheets
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