BiologicalActivity
PositiveallostericmodulatorofGABABreceptors.IncreasesthepotencyandefficacyofGABAatbothnativeandrecombinantGABABreceptors(EC50valuesare5.37and4.60μMrespectively)andenhancestheinhibitoryeffectoftheagoNISTL-baclofeninculturedcorticalneurons.Reducesoperantself-administrationofethanolinalcohol-preferringratsfollowingi.p.administration.
CompoundLibraries
CGP7930isalsoofferedaspartoftheTocriscreenPlus.FindoutmoreaboutcompoundlibrariesavailablefromTocris.
TechnicalData
| M.Wt | 292.46 |
| Formula | C19H32O2 |
| Storage | DesiccateatRT |
| Purity | ≥98%(HPLC) |
| CASNumber | 57717-80-3 |
| PubChemID | 5024764 |
| InChIKey | XLWJPQQFJNGUPA-UHFFFAOYSA-N |
| Smiles | CC(C)(CO)CC1=CC(=C(O)C(=C1)C(C)(C)C)C(C)(C)C |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 29.25 | 100 | |
| ethanol | 29.25 | 100 |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight292.46.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 3.42mL | 17.1mL | 34.19mL |
| 5mM | 0.68mL | 3.42mL | 6.84mL |
| 10mM | 0.34mL | 1.71mL | 3.42mL |
| 50mM | 0.07mL | 0.34mL | 0.68mL |
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ProductDatasheets
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