BiologicalActivity
ImidazoleantimycoticandcytochromeP450inhibitor.InhibitsCa2+-activatedK+current(IC50=3μM)andL-typeCa2+current;increasesthefiringrateofactionpotentials.Exhibitsantiproliferativeactivityinvitroandinvivo.AlsoaninverseagoNISTofthehumanconstitutiveandrostanereceptor(hCAR).
CompoundLibraries
ClotrimazoleisalsoofferedaspartoftheTocriscreenPlusandTocriscreenLibraryofFDA-ApprovedCompounds.FindoutmoreaboutcompoundlibrariesavailablefromTocris.
TechnicalData
| M.Wt | 344.84 |
| Formula | C22H17ClN2 |
| Storage | StoreatRT |
| Purity | ≥99%(HPLC) |
| CASNumber | 23593-75-1 |
| PubChemID | 2812 |
| InChIKey | VNFPBHJOKIVQEB-UHFFFAOYSA-N |
| Smiles | ClC1=CC=CC=C1C(C3=CC=CC=C3)(C4=CC=CC=C4)N2C=CN=C2 |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 25.86 | 75 | |
| ethanol | 34.48 | 100 |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight344.84.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 2.9mL | 14.5mL | 29mL |
| 5mM | 0.58mL | 2.9mL | 5.8mL |
| 10mM | 0.29mL | 1.45mL | 2.9mL |
| 50mM | 0.06mL | 0.29mL | 0.58mL |
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ProductDatasheets
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