BiologicalActivity
GLIantagonistthatinhibitsGLI1andGLI2-inducedtranscription(IC50~5μM).Inhibitsthehedgehog(Hh)signalingpathwaydownstreamofSMOandSUFUcausingGLI1nuclearaccumulation.Displaysantiproliferativeandantitumoractivityinvivo.InhibitsthepluripotencyfactorsOct4,Sox-2,Nanogandc-Mycinpancreaticcancerstemcells.
CompoundLibraries
GANT61isalsoofferedaspartoftheTocriscreenPlusandTocriscreenStemCellToolbox.FindoutmoreaboutcompoundlibrariesavailablefromTocris.
TechnicalData
| M.Wt | 429.61 |
| Formula | C27H35N5 |
| Storage | Storeat-20°C |
| Purity | ≥98%(HPLC) |
| CASNumber | 500579-04-4 |
| PubChemID | 421610 |
| InChIKey | KVQOGDQTWWCZFX-UHFFFAOYSA-N |
| Smiles | CN(C1=CC=CC=C1CN2CCCN(CC4=C(N(C)C)C=CC=C4)C2C3=CC=NC=C3)C |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 21.48 | 50 | |
| ethanol | 42.96 | 100 |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight429.61.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 2.33mL | 11.64mL | 23.28mL |
| 5mM | 0.47mL | 2.33mL | 4.66mL |
| 10mM | 0.23mL | 1.16mL | 2.33mL |
| 50mM | 0.05mL | 0.23mL | 0.47mL |
MolarityCalculator
ReconstitutionCalculator
DilutionCalculator
ProductDatasheets
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