Tocris/GW 4064/2473/10/10毫克-免疫在线蚂蚁淘旗下平台

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商品详细Tocris/GW 4064/2473/10/10毫克

Tocris/GW 4064/2473/10/10毫克

商品编号： 2473/10

品牌： Tocris Bioscience

市场价： ¥2780.00

美元价： 1668.00

产地：美国(厂家直采)

公司：

产品分类：受体

公司分类： Receptors

联系Q Q： 3392242852

电话号码： 4000-520-616

电子邮箱： info@ebiomall.com

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商品介绍

Description:SelectivefarnesoidXreceptor(FXR)agoNIST

ChemicalName:3-[2-[2-Chloro-4-[[3-(2,6-dichlorophenyl)-5-(1-methylethyl)-4-isoxazolyl]methoxy]phenyl]ethenyl]benzoicacid

Purity:≥97%(HPLC)

BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences

BiologicalActivity

Selective,non-steroidalfarnesoidXreceptor(FXR)agonist(EC₅₀=15nM).Displaysnoactivityatothernuclearreceptorsatconcentrationsupto1μM.Improveshyperglycaemiaandhyperlipidemiaindiabeticdb/dbmice.Showntosuppressautophagyinnutrient-deprivedmousehepatocytes.

LicensingInformation

SoldforresearchpurposesunderagreementfromGlaxoSmithKline

TechnicalData

M.Wt	542.84
Formula	C₂₈H₂₂Cl₃NO₄
Storage	Desiccateat+4°C
Purity	≥97%(HPLC)
CASNumber	278779-30-9
PubChemID	9893571
InChIKey	BYTNEISLBIENSA-MDZDMXLPSA-N
Smiles	CC(C)C1=C(COC2=CC(Cl)=C(C=CC3=CC=CC(=C3)C(O)=O)C=C2)C(=NO1)C1=C(Cl)C=CC=C1Cl

Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.

AllTocrisproductsareintendedforlaboratoryresearchuseonly.

SolubilityData

	Solvent	MaxConc.mg/mL	MaxConc.mM
Solubility
	DMSO	54.3	100
	ethanol	5.43	10

PreparingStockSolutions

Thefollowingdataisbasedontheproductmolecularweight542.84.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.

Concentration/SolventVolume/Mass	1mg	5mg	10mg
1mM	1.84mL	9.21mL	18.42mL
5mM	0.37mL	1.84mL	3.68mL
10mM	0.18mL	0.92mL	1.84mL
50mM	0.04mL	0.18mL	0.37mL

ProductDatasheets

CertificateofAnalysis/ProductDatasheet

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BiologicalActivity

LicensingInformation

TechnicalData

SolubilityData

PreparingStockSolutions

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