Tocris/HLI 373/3503/50/50毫克-免疫在线蚂蚁淘旗下平台

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Tocris/HLI 373/3503/50/50毫克

商品编号： 3503/50

品牌： Tocris Bioscience

市场价： ¥12900.00

美元价： 7740.00

产地：美国(厂家直采)

公司：

产品分类：连接酶

公司分类： ligase

联系Q Q： 3392242852

电话号码： 4000-520-616

电子邮箱： info@ebiomall.com

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商品介绍

Description:Hdm2inhibitor;activatesp53-dependenttranscription

ChemicalName:5-[[3-Dimethylamino)propyl]amino]-3,10-dimethylpyrimido[4,5-b]quinoline-2,4(3H,10H)-dionedihydrochloride

Purity:≥99%(HPLC)

BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences

BiologicalActivity

InhibitorofHdm2ubiquitinligase(E3).BlocksHdm2-mediatedubiquitylationandproteasomaldegradationofp53;activatesp53-dependenttranscription.Inducesapoptosisinseveraltumorcelllinesthatexpresswild-typep53suchasLOX-IMVI,A549,HT1080andU2OS.

TechnicalData

M.Wt	414.33
Formula	C₁₈H₂₃N₅O₂.2HCl
Storage	DesiccateatRT
Purity	≥99%(HPLC)
CASNumber	502137-98-6
PubChemID	72193867
InChIKey	WUEMKAQTAIRDOA-UHFFFAOYSA-N
Smiles	CN2C1=CC=CC=C1C(NCCCN(C)C)=C3C2=NC(N(C)C3=O)=O.Cl.Cl

Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.

AllTocrisproductsareintendedforlaboratoryresearchuseonly.

SolubilityData

	Solvent	MaxConc.mg/mL	MaxConc.mM
Solubility
	DMSO	3.78	10
	water	37.79	100

PreparingStockSolutions

Thefollowingdataisbasedontheproductmolecularweight414.33.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.

Concentration/SolventVolume/Mass	1mg	5mg	10mg
1mM	2.41mL	12.07mL	24.14mL
5mM	0.48mL	2.41mL	4.83mL
10mM	0.24mL	1.21mL	2.41mL
50mM	0.05mL	0.24mL	0.48mL

ProductDatasheets

CertificateofAnalysis/ProductDatasheet

SafetyDatasheet

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BiologicalActivity

TechnicalData

SolubilityData

PreparingStockSolutions

MolarityCalculator

ReconstitutionCalculator

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