BiologicalActivity
PromotesdifferentiationofhumanESCsandiPSCsintocardiomyocyteswhenusedafterdaythreeinculture;differentiationefficiencyincreaseswhenusedafterinitialculturewithCHIR99021(Cat.No.4423).InducesdownregulationofWntsignalingtargetgenes;inhibitscanonicalWntsignalinginamannerdistinctfromotherknownWntinhibitors.
CompoundLibraries
KY02111isalsoofferedaspartoftheTocriscreenPlusandTocriscreenStemCellToolbox.FindoutmoreaboutcompoundlibrariesavailablefromTocris.
TechnicalData
| M.Wt | 376.86 |
| Formula | C18H17ClN2O3S |
| Storage | Storeat+4°C |
| Purity | ≥99%(HPLC) |
| CASNumber | 1118807-13-8 |
| PubChemID | 8582409 |
| InChIKey | LXFKEVQQSKQXPR-UHFFFAOYSA-N |
| Smiles | O=C(CCC3=CC=C(OC)C(OC)=C3)NC2=NC1=CC=C(Cl)C=C1S2 |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 18.84 | 50 |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight376.86.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 2.65mL | 13.27mL | 26.54mL |
| 5mM | 0.53mL | 2.65mL | 5.31mL |
| 10mM | 0.27mL | 1.33mL | 2.65mL |
| 50mM | 0.05mL | 0.27mL | 0.53mL |
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ProductDatasheets
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