BiologicalActivity
Potentandselectivebreastcancerresistanceproteinmultidrugtransporter(BCRP)inhibitor(EC90=26nM).Displays>200-foldselectivityoverP-gpandMRP-1transporters.IncreasesintracellulardrugaccumulationandreversesBCRP-mediatedmultidrugresistance.InhibitsABCB1andABCC1athigherconcentrations.Rapidlymetabolizedinratplasma.
CompoundLibraries
Ko143isalsoofferedaspartoftheTocriscreenPlus.FindoutmoreaboutcompoundlibrariesavailablefromTocris.
TechnicalData
| M.Wt | 469.57 |
| Formula | C26H35N3O5 |
| Storage | Storeat-20°C |
| Purity | ≥99%(HPLC) |
| CASNumber | 461054-93-3 |
| PubChemID | 10322450 |
| InChIKey | NXNRAECHCJZNRF-JBACZVJFSA-N |
| Smiles | O=C(N[C@H]4CCC(OC(C)(C)C)=O)[C@]3([H])CC1=C([C@H](CC(C)C)N3C4=O)NC2=C1C=CC(OC)=C2 |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 23.48 | 50 | |
| ethanol | 46.96 | 100 |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight469.57.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 2.13mL | 10.65mL | 21.3mL |
| 5mM | 0.43mL | 2.13mL | 4.26mL |
| 10mM | 0.21mL | 1.06mL | 2.13mL |
| 50mM | 0.04mL | 0.21mL | 0.43mL |
MolarityCalculator
ReconstitutionCalculator
DilutionCalculator
ProductDatasheets
本网站将在规定时间内给予删除等相关处理。
