Tocris/L189/3561/10/10 mg-免疫在线蚂蚁淘旗下平台

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商品详细Tocris/L189/3561/10/10 mg

Tocris/L189/3561/10/10 mg

商品编号： 3561/10

品牌： Tocris Bioscience

市场价： ¥3180.00

美元价： 1908.00

产地：美国(厂家直采)

公司：

产品分类：连接酶

公司分类： ligase

联系Q Q： 3392242852

电话号码： 4000-520-616

电子邮箱： info@ebiomall.com

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商品介绍

Description:DNAligaseI,IIIandIVinhibitor

ChemicalName:6-Amino-2,3-dihydro-5-[(phenylmethylene)amino]-2-4(1H)-pyrimidineone

BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences

BiologicalActivity

DNAligaseI,IIIandIVinhibitor(IC₅₀valuesare5,9and5μMrespectively)thatblocksDNAbinding(K_i=5μMforDNAligaseI).Preferentiallyinhibitsstep2oftheligationreaction,andinhibitsbaseexcisionrepair(BER)andnon-homologousendjoining(NHEJ).SpecificallysensitizescancercellstoDNAdamageandincreasesthecytotoxicityofDNA-damagingagents.

TechnicalData

M.Wt	246.29
Formula	C₁₁H₁₀N₄OS
Storage	Storeat-20°C
CASNumber	64232-83-3
PubChemID	824710
InChIKey	SAKOXVNKDMWWLF-UHFFFAOYSA-N
Smiles	S=C1NC(N)=C(/N=C/C2=CC=CC=C2)C(N1)=O

Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.

AllTocrisproductsareintendedforlaboratoryresearchuseonly.

SolubilityData

	Solvent	MaxConc.mg/mL	MaxConc.mM
Solubility
Solubility	DMSO	24.63	100

PreparingStockSolutions

Thefollowingdataisbasedontheproductmolecularweight246.29.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.

Concentration/SolventVolume/Mass	1mg	5mg	10mg
1mM	4.06mL	20.3mL	40.6mL
5mM	0.81mL	4.06mL	8.12mL
10mM	0.41mL	2.03mL	4.06mL
50mM	0.08mL	0.41mL	0.81mL

ProductDatasheets

CertificateofAnalysis/ProductDatasheet

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BiologicalActivity

TechnicalData

SolubilityData

PreparingStockSolutions

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