BiologicalActivity
Tetracyclineantibiotic.Displaysneuroprotective,antiapoptotic,anti-inflammatoryandantimicrobialeffects.Actsasamatrixmetalloproteinase(MMP)inhibitor;attenuatesdiseaseseverityinmousemodelsofmultiplesclerosis.Orallyactiveandbrainpenetrant.Allowsformationofextendedpluripotentstem(EPS)cellsincombinationwithCHIR99021(Cat.No.4423),(S)-(+)-Dimethindenemaleate(Cat.No.1425)andhumanleukemiainhibitoryfactor.
TechnicalData
| M.Wt | 493.94 |
| Formula | C23H27N3O7.HCl |
| Storage | Desiccateat+4°C |
| Purity | ≥98%(HPLC) |
| CASNumber | 13614-98-7 |
| PubChemID | 54685925 |
| InChIKey | WTJXVDPDEQKTCV-VQAITOIOSA-N |
| Smiles | NC(C4=C(O)[C@@H](N(C)C)[C@@]3([H])[C@](C4=O)(O)C(O)=C2C(C1=C(O)C=CC(N(C)C)=C1C[C@]([H])2C3)=O)=O.Cl |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 49.39 | 100 | |
| water | 12.35 | 25 |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight493.94.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 2.02mL | 10.12mL | 20.25mL |
| 5mM | 0.4mL | 2.02mL | 4.05mL |
| 10mM | 0.2mL | 1.01mL | 2.02mL |
| 50mM | 0.04mL | 0.2mL | 0.4mL |
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