BiologicalActivity
Inhibitorofp53;reversIBLyblocksp53-dependenttranscriptionalactivationandapoptosis.Protectsagainstneuronaldeathinmodelsofstrokeandneurodegenerativedisorders.Activeinvivo;protectsmicefromtheside-effectsofcancertherapyassociatedwithp53induction.Supressesself-renewalofembryonicstemcells.Alsoarylhydrocarbonreceptor(AHR)agonist,causesupregulationofAHRtargetgeneCYP1A1(EC50=1.1μM).Cyclicanalogavailable(Cat.No.3843).
CompoundLibraries
Pifithrin-αhydrobromideisalsoofferedaspartoftheTocriscreenStemCellToolbox.FindoutmoreaboutcompoundlibrariesavailablefromTocris.
TechnicalData
| M.Wt | 367.3 |
| Formula | C16H18N2OS.HBr |
| Storage | Desiccateat-20°C |
| CASNumber | 63208-82-2 |
| PubChemID | 9929138 |
| InChIKey | HAGVCKULCLQGRF-UHFFFAOYSA-N |
| Smiles | Br.CC1=CC=C(C=C1)C(=O)CN1C(=N)SC2=C1CCCC2 |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 36.73 | 100 |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight367.3.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 2.72mL | 13.61mL | 27.23mL |
| 5mM | 0.54mL | 2.72mL | 5.45mL |
| 10mM | 0.27mL | 1.36mL | 2.72mL |
| 50mM | 0.05mL | 0.27mL | 0.54mL |
MolarityCalculator
ReconstitutionCalculator
DilutionCalculator
ProductDatasheets
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