BiologicalActivity
Selectiveinhibitoroftransforminggrowthfactor-βreceptorI(ALK5,TGF-βRI)(IC50=14.3nM).InhibitsTGF-β1-inducedsmad2/3nuclearlocalizationandTGF-βRI-inducedmRNAexpressioninkidneycells.Attenuatesbleomycin-inducedpulmonaryfibrosis.
LicensingInformation
SoldwiththepermissionofGlaxoSmithKline
CompoundLibraries
SB525334isalsoofferedaspartoftheTocriscreenPlusandTocriscreenKinaseInhibitorToolboxI.FindoutmoreaboutcompoundlibrariesavailablefromTocris.
TechnicalData
| M.Wt | 343.42 |
| Formula | C21H21N5 |
| Storage | Storeat-20°C |
| Purity | ≥97%(HPLC) |
| CASNumber | 356559-20-1 |
| PubChemID | 9967941 |
| InChIKey | DKPQHFZUICCZHF-UHFFFAOYSA-N |
| Smiles | CC1=NC(C4=C(NC(C(C)(C)C)=N4)C2=CC=C(N=CC=N3)C3=C2)=CC=C1 |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| 1eq.HCl | 34.34 | 100 | |
| DMSO | 34.34 | 100 |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight343.42.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 2.91mL | 14.56mL | 29.12mL |
| 5mM | 0.58mL | 2.91mL | 5.82mL |
| 10mM | 0.29mL | 1.46mL | 2.91mL |
| 50mM | 0.06mL | 0.29mL | 0.58mL |
MolarityCalculator
ReconstitutionCalculator
DilutionCalculator
ProductDatasheets
本网站将在规定时间内给予删除等相关处理。
