Tocris/SIS3/5291/10/10毫克-免疫在线蚂蚁淘旗下平台

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Tocris/SIS3/5291/10/10毫克

商品编号： 5291/10

品牌： Tocris Bioscience

市场价： ¥4700.00

美元价： 2820.00

产地：美国(厂家直采)

公司：

产品分类：氨基酸

公司分类： aminophenol

联系Q Q： 3392242852

电话号码： 4000-520-616

电子邮箱： info@ebiomall.com

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商品介绍

Description:SelectiveSmad3inhibitor;inhibitsTGF-βR1signaling

ChemicalName:1,2,3,4-Tetrahydro-6,7-dimethoxy-2-[(2E)-3-(1-phenyl-1H-pyrrolo[2,3-b]pyridin-3-yl)-1-oxo-2-propenyl]-isoquinolinehydrochloride

Purity:≥98%(HPLC)

BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences

BiologicalActivity

SelectiveSmad3inhibitor;attenuatesTGF-β1-dependentSmad3phosphorylationandDNAbinding.HasnoeffectonSmad2,p38MAPK,ERKorPI3-kinasesignaling.InhibitsTGF-β1-inducedmyofibroblastdifferentiationofdermalfibroblasts.AlsoinhibitsTGF-β2-inducedendothelialcelldifferentiationiniPSCs.

CompoundLibraries

SIS3isalsoofferedaspartoftheTocriscreenPlus.FindoutmoreaboutcompoundlibrariesavailablefromTocris.

TechnicalData

M.Wt	489.99
Formula	C₂₈H₂₇N₃O₃.HCl
Storage	Storeat-20°C
Purity	≥98%(HPLC)
CASNumber	521984-48-5
PubChemID	16079005
InChIKey	CDKIEBFIMCSCBB-CALJPSDSSA-N
Smiles	O=C(N4CCC(C=C(OC)C(OC)=C5)=C5C4)/C=C/C2=C(C3=CC=CC=C3)N(C)C1=NC=CC=C12.Cl

Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.

AllTocrisproductsareintendedforlaboratoryresearchuseonly.

SolubilityData

	Solvent	MaxConc.mg/mL	MaxConc.mM
Solubility
Solubility	DMSO	49	100

PreparingStockSolutions

Thefollowingdataisbasedontheproductmolecularweight489.99.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.

Concentration/SolventVolume/Mass	1mg	5mg	10mg
1mM	2.04mL	10.2mL	20.41mL
5mM	0.41mL	2.04mL	4.08mL
10mM	0.2mL	1.02mL	2.04mL
50mM	0.04mL	0.2mL	0.41mL

ProductDatasheets

CertificateofAnalysis/ProductDatasheet

SafetyDatasheet

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BiologicalActivity

CompoundLibraries

TechnicalData

SolubilityData

PreparingStockSolutions

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ProductDatasheets