Tocris/Tariquidar二盐酸盐/5757/10/10 mg-免疫在线蚂蚁淘旗下平台

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商品详细Tocris/Tariquidar二盐酸盐/5757/10/10 mg

Tocris/Tariquidar二盐酸盐/5757/10/10 mg

商品编号： 5757/10

品牌： Tocris Bioscience

市场价： ¥3580.00

美元价： 2148.00

产地：美国(厂家直采)

公司：

产品分类：转运体

公司分类： Transporters

联系Q Q： 3392242852

电话号码： 4000-520-616

电子邮箱： info@ebiomall.com

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商品介绍

Description:PotentP-glycoprotein(P-gp)inhibitor

ChemicalName:N-[2-[[[4-[2-(3,4-dihydro-6,7-dimethoxy-2(1H)-isoquinolinyl)ethyl]phenyl]amino]carbonyl]-4,5-dimethoxyphenyl]-3-quinolinecarbxamidedihydrochloride

Purity:≥98%(HPLC)

BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences

BiologicalActivity

PotentP-glycoprotein(P-gp)inhibitor(IC₅₀=5.1nM).ReversesdrugresistanceinmultipleMDRcelllines.Actsasasubstrateforbreastcancerresistanceprotein(BCRP)atlowconcentrationsandactsasaninhibitorofBCRPwhenusedat>100nMconcentration.Potentiatesthecytotoxiceffectsofdoxorubicin(Cat.No.2252)andmitoxantrone(Cat.No.4250)invitro.

TechnicalData

M.Wt	719.66
Formula	C₃₈H₃₈N₄O₆.2HCl
Storage	Storeat-20°C
Purity	≥98%(HPLC)
PubChemID	121513890
InChIKey	ZJCJRGRTDKIFJJ-UHFFFAOYSA-N
Smiles	O=C(C1=CC(OC)=C(OC)C=C1NC(C2=CN=C(C=CC=C3)C3=C2)=O)NC(C=C4)=CC=C4CCN5CC6=CC(OC)=C(OC)C=C6CC5.Cl.Cl

Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.

AllTocrisproductsareintendedforlaboratoryresearchuseonly.

SolubilityData

	Solvent	MaxConc.mg/mL	MaxConc.mM
Solubility
Solubility	DMSO	71.97	100

PreparingStockSolutions

Thefollowingdataisbasedontheproductmolecularweight719.66.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.

Concentration/SolventVolume/Mass	1mg	5mg	10mg
1mM	1.39mL	6.95mL	13.9mL
5mM	0.28mL	1.39mL	2.78mL
10mM	0.14mL	0.69mL	1.39mL
50mM	0.03mL	0.14mL	0.28mL

ProductDatasheets

CertificateofAnalysis/ProductDatasheet

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BiologicalActivity

TechnicalData

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