BiologicalActivity
SelectivePPARγreceptoragonist(EC50valuesare780and555nMatmurineandhumanPPARγreceptorsrespectively).DisplaysnoactivityatPPARαorPPARδreceptors.Antidiabeticagent;exertspotentglucose-loweringeffectsininsulin-resistantdiabeticmice.Displaysanti-invasiveeffectonhumanbreastcancercells;reducesmigration,adhesionandspreADIngonfibronectin-coatedplates.Alsoinhibitscellgrowthofhematopoieticcelllines.Inhibitslamellipodiaformationandactinpolymerization.
CompoundLibraries
TroglitazoneisalsoofferedaspartoftheTocriscreenPlusandTocriscreenStemCellToolbox.FindoutmoreaboutcompoundlibrariesavailablefromTocris.
TechnicalData
| M.Wt | 441.54 |
| Formula | C24H27NO5S |
| Storage | Storeat-20°C |
| Purity | ≥97%(HPLC) |
| CASNumber | 97322-87-7 |
| PubChemID | 5591 |
| InChIKey | GXPHKUHSUJUWKP-UHFFFAOYSA-N |
| Smiles | CC1=C2C(CCC(COC3=CC=C(CC4C(NC(S4)=O)=O)C=C3)(C)O2)=C(C)C(O)=C1C |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 44.15 | 100 | |
| ethanol | 4.42 | 10 |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight441.54.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 2.26mL | 11.32mL | 22.65mL |
| 5mM | 0.45mL | 2.26mL | 4.53mL |
| 10mM | 0.23mL | 1.13mL | 2.26mL |
| 50mM | 0.05mL | 0.23mL | 0.45mL |
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ProductDatasheets
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