Tocris/WAY 252623/5951/10/10毫克-免疫在线蚂蚁淘旗下平台

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Tocris/WAY 252623/5951/10/10毫克

商品编号： 5951/10

品牌： Tocris Bioscience

市场价： ¥2980.00

美元价： 1788.00

产地：美国(厂家直采)

公司：

产品分类：受体

公司分类： Receptors

联系Q Q： 3392242852

电话号码： 4000-520-616

电子邮箱： info@ebiomall.com

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商品介绍

Description:PotentLXRagoNIST

ChemicalName:2-[(2-Chloro-4-fluorophenyl)methyl]-3-(4-fluorophenyl)-7-(trifluoromethyl)-2H-indazole

Purity:≥98%(HPLC)

BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences

BiologicalActivity

PotentLXRagonist(IC₅₀valuesare24and179nMforLXRβandLXRα,respectively).ReducestotalserumcholesterolandLDLcholesterol,andinhibitslesiongrowthinmodelsofatherosclerosis.IncreasesABCA1andABCG1mRNAlevelsinratperipheralbloodcells.Orallybioavailable.

LicensingInformation

SoldforresearchpurposesunderagreementfromPfizerInc.

TechnicalData

M.Wt	422.78
Formula	C₂₁H₁₂ClF₅N₂
Storage	Storeat+4°C
Purity	≥98%(HPLC)
CASNumber	875787-07-8
PubChemID	16734800
InChIKey	KYWWJENKIMRJBI-UHFFFAOYSA-N
Smiles	ClC1=CC(F)=CC=C1CN2N=C3C(C(F)(F)F)=CC=CC3=C2C4=CC=C(F)C=C4

Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.

AllTocrisproductsareintendedforlaboratoryresearchuseonly.

SolubilityData

	Solvent	MaxConc.mg/mL	MaxConc.mM
Solubility
	DMSO	42.28	100
	ethanol	42.28	100

PreparingStockSolutions

Thefollowingdataisbasedontheproductmolecularweight422.78.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.

Concentration/SolventVolume/Mass	1mg	5mg	10mg
1mM	2.37mL	11.83mL	23.65mL
5mM	0.47mL	2.37mL	4.73mL
10mM	0.24mL	1.18mL	2.37mL
50mM	0.05mL	0.24mL	0.47mL

ProductDatasheets

CertificateofAnalysis/ProductDatasheet

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BiologicalActivity

LicensingInformation

TechnicalData

SolubilityData

PreparingStockSolutions

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