Tocris/Zosuquidar trihydrochloride/5456/10/10 mg-免疫在线蚂蚁淘旗下平台

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商品详细Tocris/Zosuquidar trihydrochloride/5456/10/10 mg

Tocris/Zosuquidar trihydrochloride/5456/10/10 mg

商品编号： 5456/10

品牌： Tocris Bioscience

市场价： ¥3700.00

美元价： 2220.00

产地：美国(厂家直采)

公司：

产品分类：转运体

公司分类： Transporters

联系Q Q： 3392242852

电话号码： 4000-520-616

电子邮箱： info@ebiomall.com

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商品介绍

Description:HighaffinityP-gpinhibitor

AlternativeNames:LY335979

ChemicalName:(αR)-4-[(1aα,6α,10bα)-1,1-Difluoro-1,1a,6,10b-tetrahydrodibenzo[a,e]cyclopropa[c]cyclohepten-6-yl]-α-[(5-quinolinyloxy)methyl]-1-piperazineethanoltrihydrochloride

Purity:≥98%(HPLC)

BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences

BiologicalActivity

HighaffinityP-glycoprotein(P-gp)inhibitor(K_d=79nM).Restoresdoxorubicin(Cat.No.2252)sensitivityinP-gp-expressingmultidrug(MDR)resistantcancercelllines.Alsopotentiatesantitumorefficacyoftaxol(Cat.No.1097)inaMDRhumannon-smallcelllungcarcinomaxenograftmousemodel.

CompoundLibraries

ZosuquidartrihydrochlorideisalsoofferedaspartoftheTocriscreenPlus.FindoutmoreaboutcompoundlibrariesavailablefromTocris.

TechnicalData

M.Wt	636.99
Formula	C₃₂H₃₁F₂N₃O₂.3HCl
Storage	Storeat-20°C
Purity	≥98%(HPLC)
CASNumber	167465-36-3
PubChemID	153997
InChIKey	ZPFVQKPWGDRLHL-ZLYBXYBFSA-N
Smiles	F[C@@]2(F)[C@H]1C3=C(C=CC=C3)[C@H](N5CCN(C[C@H](COC6=CC=CC7=C6C=CC=N7)O)CC5)C4=C(C=CC=C4)[C@H]12.Cl.Cl.Cl

Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.

AllTocrisproductsareintendedforlaboratoryresearchuseonly.

SolubilityData

	Solvent	MaxConc.mg/mL	MaxConc.mM
Solubility
Solubility	DMSO	31.85	50

PreparingStockSolutions

Thefollowingdataisbasedontheproductmolecularweight636.99.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.

Concentration/SolventVolume/Mass	1mg	5mg	10mg
1mM	1.57mL	7.85mL	15.7mL
5mM	0.31mL	1.57mL	3.14mL
10mM	0.16mL	0.78mL	1.57mL
50mM	0.03mL	0.16mL	0.31mL

ProductDatasheets

CertificateofAnalysis/ProductDatasheet

SafetyDatasheet

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BiologicalActivity

CompoundLibraries

TechnicalData

SolubilityData

PreparingStockSolutions

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ProductDatasheets