BiologicalActivity
PotentinhibitorofTGF-βtypeIreceptorALK5kinase,typeIactivin/nodalreceptorALK4andtypeInodalreceptorALK7(IC50valuesare12,45and7.5nMrespectively).BlocksphosphorylationofSmad2andinhibitsTGF-β-inducedepithelial-to-mesenchymaltransition.OnlyweaklyinhibitsALK-1,-2,-3,-6andMAPKactivity.MorepotentthanSB431542(Cat.No.1614).Inhibitsdifferentiationofratinducedpluripotentstemcells(riPSCs)andincreasesclonalexpansionefficiency.Helpsmaintainhomogeneityandlong-terminvitroself-renewalofhumaniPSCs.
CompoundLibraries
A83-01isalsoofferedaspartoftheTocriscreenStemCellToolbox.FindoutmoreaboutcompoundlibrariesavailablefromTocris.
TechnicalData
| M.Wt | 421.52 |
| Formula | C25H19N5S |
| Storage | Storeat-20°C |
| Purity | ≥98%(HPLC) |
| CASNumber | 909910-43-6 |
| PubChemID | 16218924 |
| InChIKey | HIJMSZGHKQPPJS-UHFFFAOYSA-N |
| Smiles | S=C(NC5=CC=CC=C5)N(N=C3C4=NC(C)=CC=C4)C=C3C2=CC=NC1=CC=CC=C12 |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 21.08 | 50 |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight421.52.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 2.37mL | 11.86mL | 23.72mL |
| 5mM | 0.47mL | 2.37mL | 4.74mL |
| 10mM | 0.24mL | 1.19mL | 2.37mL |
| 50mM | 0.05mL | 0.24mL | 0.47mL |
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