BiologicalActivity
R-(-)-enantiomerofgossypol(Cat.No.1964).MimicstheBH3domainsofBcl-2,Bcl-XLandMcl-1.DisruptsheterodimerizationofBcl-2withproapoptoticfamilymembers.Inducesapoptosisinvitrothroughactivationofcaspase-9;cytotoxictomultiplemyelomaanddrug-resistantcelllines.Delaysonsetofandrogen-independentgrowthofVCaPprostatecancerxenograftsinvivo.
CompoundLibraries
AT101isalsoofferedaspartoftheTocriscreenPlus.FindoutmoreaboutcompoundlibrariesavailablefromTocris.
TechnicalData
| M.Wt | 518.56 |
| Formula | C30H30O8 |
| Storage | Storeat-20°C |
| Purity | ≥98%(HPLC) |
| CASNumber | 90141-22-3 |
| PubChemID | 3503 |
| InChIKey | QBKSWRVVCFFDOT-UHFFFAOYSA-N |
| Smiles | OC1=C(C3=C(O)C(C(C=O)=C(O)C(O)=C4C(C)C)=C4C=C3C)C(C)=CC2=C1C(C=O)=C(O)C(O)=C2C(C)C |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 51.86 | 100 | |
| ethanol | 51.86 | 100 |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight518.56.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 1.93mL | 9.64mL | 19.28mL |
| 5mM | 0.39mL | 1.93mL | 3.86mL |
| 10mM | 0.19mL | 0.96mL | 1.93mL |
| 50mM | 0.04mL | 0.19mL | 0.39mL |
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