BiologicalActivity
PotentTNKS2andTNKS1inhibitor(IC50valuesare1and3nM,respectively).Exhibits>100-foldselectivityforTNKS1/2overPARP-1,PARP-2andPARP-6.InhibitsWntsignalinginDLD-1cells(IC50=5nM).ExhibitsmoderateoralbioavailABIlity.
ExternalPortalInformation
Chemicalprobes.orgisaportalthatoffersindependentguidanceontheselectionand/orapplicationofsmallmoleculesforresearch.TheuseofAZ6102isreviewedonthechemicalprobeswebsite.
CompoundLibraries
AZ6102isalsoofferedaspartoftheTocriscreenPlus.FindoutmoreaboutcompoundlibrariesavailablefromTocris.
TechnicalData
| M.Wt | 428.53 |
| Formula | C25H28N6O |
| Storage | Storeat-20°C |
| Purity | ≥98%(HPLC) |
| CASNumber | 1645286-75-4 |
| PubChemID | 91663328 |
| InChIKey | WCPTUQOMNJBIET-CALCHBBNSA-N |
| Smiles | CC1=CC(N2C[C@H](C)N[C@H](C)C2)=NC=C1C3=CC=C(C(N4)=NC5=C(C=CN5C)C4=O)C=C3 |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 21.43 | 50 |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight428.53.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 2.33mL | 11.67mL | 23.34mL |
| 5mM | 0.47mL | 2.33mL | 4.67mL |
| 10mM | 0.23mL | 1.17mL | 2.33mL |
| 50mM | 0.05mL | 0.23mL | 0.47mL |
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ProductDatasheets
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