BiologicalActivity
Srctyrosinekinaseinhibitor.Reducestumorsize,vascularityandmetastasis,andincreasesapoptosisinhumanpancreaticcellsgrowninnudemice.Alsoexhibitsantiangiogenicactivityinvitroandinvivo.SensitizestumorcellstothecytotoxiceffectsofgemcitABIne(Cat.No.3259).
LicensingInformation
SoldwiththepermissionofAstraZenecaUKLtd.
CompoundLibraries
AZM475271isalsoofferedaspartoftheTocriscreenPlusandTocriscreenKinaseInhibitorToolboxI.FindoutmoreaboutcompoundlibrariesavailablefromTocris.
TechnicalData
| M.Wt | 442.94 |
| Formula | C23H27ClN4O3 |
| Storage | StoreatRT |
| Purity | ≥99%(HPLC) |
| CASNumber | 476159-98-5 |
| PubChemID | 5330175 |
| InChIKey | WPOXAFXHRJYEIC-UHFFFAOYSA-N |
| Smiles | ClC1=CC=C(OC)C=C1NC3=NC=NC2=CC(OCC4CCN(C)CC4)=C(OC)C=C23 |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 44.29 | 100 |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight442.94.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 2.26mL | 11.29mL | 22.58mL |
| 5mM | 0.45mL | 2.26mL | 4.52mL |
| 10mM | 0.23mL | 1.13mL | 2.26mL |
| 50mM | 0.05mL | 0.23mL | 0.45mL |
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ProductDatasheets
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