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商品详细Tocris/Akti-1/2/5773/10/10 mg

Tocris/Akti-1/2/5773/10/10 mg

商品编号： 5773/10

品牌： Tocris Bioscience

市场价： ¥3100.00

美元价： 1860.00

产地：美国(厂家直采)

公司：

产品分类：其它酶

公司分类： Other_enzymes

联系Q Q： 3392242852

电话号码： 4000-520-616

电子邮箱： info@ebiomall.com

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商品介绍

Description:PotentandselectivedualAkt1and2inhibitor

ChemicalName:1,3-Dihydro-1-[1-[[4-(6-phenyl-1H-imidazo[4,5-g]quinoxalin-7-yl)phenyl]methyl]-4-piperidinyl]-2H-benzimidazol-2-one

Purity:≥98%(HPLC)

BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences

BiologicalActivity

PotentandselectivedualAkt1and2inhibitor(IC₅₀valuesare50and210nM,respectively).SelectiveforAkt1and2overapanelofothertyrosineandserine/threoninekinases.SensitizesLnCaPcellstoTRAIL(TNF-relatedapoptosis-inducingligand)inducedapoptosis.Activeinvivo.

TechnicalData

M.Wt	551.64
Formula	C₃₄N₂₉N₇O
Storage	Storeat-20°C
Purity	≥98%(HPLC)
CASNumber	612847-09-3
PubChemID	10196499
InChIKey	BIWGYFZAEWGBAL-UHFFFAOYSA-N
Smiles	O=C1NC2=C(C=CC=C2)N1C(CC3)CCN3CC(C=C4)=CC=C4C5=NC6=CC(N=CN7)=C7C=C6N=C5C8=CC=CC=C8

Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.

AllTocrisproductsareintendedforlaboratoryresearchuseonly.

SolubilityData

	Solvent	MaxConc.mg/mL	MaxConc.mM
Solubility
Solubility	DMSO	11.03	20mMwithgentlewarming

PreparingStockSolutions

Thefollowingdataisbasedontheproductmolecularweight551.64.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.

Concentration/SolventVolume/Mass	1mg	5mg	10mg
1mM	1.81mL	9.06mL	18.13mL
5mM	0.36mL	1.81mL	3.63mL
10mM	0.18mL	0.91mL	1.81mL
50mM	0.04mL	0.18mL	0.36mL

ProductDatasheets

CertificateofAnalysis/ProductDatasheet

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SolubilityData

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