Biological Activity
GABAA receptor positive allosteric modulator. Neuroactive steroid.
Compound Libraries
Allopregnanolone is also offered as part of the Tocriscreen Plus. Find out more about compound libraries available from Tocris.
Technical Data
| M. Wt | 318.49 |
| Formula | C21H34O2 |
| Storage | Store at RT |
| CAS Number | 516-54-1 |
| PubChem ID | 92786 |
| InChI Key | AURFZBICLPNKBZ-SYBPFIFISA-N |
| Smiles | C[C@@]12[C@](CC[C@]3([H])[C@@]([H])2CC[C@@]4(C)[C@]([H])3CC[C@@H]4[C@](C)=O)([H])C[C@H](O)CC1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 31.85 | 100 | |
| ethanol | 31.85 | 100 |
Preparing Stock Solutions
The following data is based on the product molecular weight 318.49. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.14 mL | 15.7 mL | 31.4 mL |
| 5 mM | 0.63 mL | 3.14 mL | 6.28 mL |
| 10 mM | 0.31 mL | 1.57 mL | 3.14 mL |
| 50 mM | 0.06 mL | 0.31 mL | 0.63 mL |
Molarity Calculator
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Product Datasheets
References
References are publications that support the products' biological activity.
Puia et al (1990) Neurosteroids act on recombinant human GABAA receptors. Neuron 4 759 PMID: 2160838
Belelli and Lambert (2005) Neurosteroids: endogenous regulators of the GABAA receptor. Nat.Rev.Neurosci. 6 565 PMID: 15959466
Agis-Balboa et al (2006) Characterization of brain neurons that express enzymes mediating neurosteroid biosynthesis. Proc.Natl.Acad.Sci.USA 103 14602 PMID:
Keywords: Allopregnanolone, supplier, GABAA, receptors, positive, allosteric, modulators, neuroactive, steroid, 3a,5a-THPROG, GABAA, Receptors, GABAA, Receptors, Tocris Bioscience
