Biological Activity
Specific inhibitor of aldose reductase (IC50 = 148 μM). Attenuates glucose-induced angiotensin II production in rat vascular smooth muscle in vitro.
Technical Data
| M. Wt | 255.23 |
| Formula | C14H9NO4 |
| Storage | Store at RT |
| CAS Number | 51411-04-2 |
| PubChem ID | 2120 |
| InChI Key | GCUCIFQCGJIRNT-UHFFFAOYSA-N |
| Smiles | OC(=O)CN1C(=O)C2=CC=CC3=CC=CC(C1=O)=C23 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 25.52 | 100 |
Preparing Stock Solutions
The following data is based on the product molecular weight 255.23. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.92 mL | 19.59 mL | 39.18 mL |
| 5 mM | 0.78 mL | 3.92 mL | 7.84 mL |
| 10 mM | 0.39 mL | 1.96 mL | 3.92 mL |
| 50 mM | 0.08 mL | 0.39 mL | 0.78 mL |
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Product Datasheets
References
References are publications that support the products' biological activity.
Barski et al (1996) The C-terminal loop of aldehyde reductase determines the substrate and inhibitor specificity. Biochemistry 35 14276 PMID: 8916913
Ehrig et al (1994) Mechanism of aldose reductase inhibition: binding of NADP+/NADPH and alrestatin-like inhibitors. Biochemistry 33 7157 PMID: 8003482
Lavrentyev et al (2007) Mechanism of high glucose-induced angiotensin II production in rat vascular smooth muscle cells. Circ.Res. 101 455 PMID: 17626897
Keywords: Alrestatin, supplier, Aldose, reductases, inhibitors, inhibits, Carbohydrate, Metabolism, Aldose, Reductase, Aldose, Reductase, Tocris Bioscience
