Biological Activity
Adenine receptor agonist (Ki = 0.0341 μM in HEK293 cells expressing an adenine binding site). Displays 190-fold increased potency at the human binding site over the rat adenine receptor (rAde1R) (Ki = 6.51 μM).
Technical Data
| M. Wt | 150.14 |
| Formula | C5H6N6 |
| Storage | Store at +4°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 28128-33-8 |
| PubChem ID | 4371597 |
| InChI Key | PFUVOLUPRFCPMN-UHFFFAOYSA-N |
| Smiles | NC2=NC1=NC=NC(N)=C1N2 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| 2eq.HCl | 15.01 | 100 | |
| DMSO | 7.51 | 50 |
Preparing Stock Solutions
The following data is based on the product molecular weight 150.14. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 6.66 mL | 33.3 mL | 66.6 mL |
| 5 mM | 1.33 mL | 6.66 mL | 13.32 mL |
| 10 mM | 0.67 mL | 3.33 mL | 6.66 mL |
| 50 mM | 0.13 mL | 0.67 mL | 1.33 mL |
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Product Datasheets
References
References are publications that support the products' biological activity.
Borrmann et al (2009) Structure-activity relationships of adenine and deazaadenine derivatives as ligands for adenine receptors, a new purinergic receptor family. J.Med.Chem. 52 5974 PMID: 19731917
Bender et al (2002) Characterization of an orphan G protein-coupled receptor localized in the dorsal root ganglia reveals adenine as a signaling molecule. Proc.Natl.Acad.Sci. 99 8573 PMID:
Keywords: 8-Aminoadenine, supplier, p0, adenine, receptors, agonists, purinergic, signaling, signalling, Adenine, Receptor, Adenine, Receptor, Tocris Bioscience
