Biological Activity
H2 antagonist (KB values are 220 and 280 nM at human and guinea pig H2 receptors respectively) and precursor for the synthesis of the [125I]-iodo derivative.
Technical Data
| M. Wt | 477.6 |
| Formula | C26H35N7O2 |
| Storage | Store at +4°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 140873-26-3 |
| PubChem ID | 164435 |
| InChI Key | CICDSYWWNDGAGD-UHFFFAOYSA-N |
| Smiles | O=C(C3=CC=C(N)C=C3)NCCNC(NCCCOC1=CC(CN2CCCCC2)=CC=C1)=NC#N |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 47.76 | 100 | |
| ethanol | 47.76 | 100 |
Preparing Stock Solutions
The following data is based on the product molecular weight 477.6. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.09 mL | 10.47 mL | 20.94 mL |
| 5 mM | 0.42 mL | 2.09 mL | 4.19 mL |
| 10 mM | 0.21 mL | 1.05 mL | 2.09 mL |
| 50 mM | 0.04 mL | 0.21 mL | 0.42 mL |
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Product Datasheets
References
References are publications that support the products' biological activity.
Hirschfield et al (1992) Iodoaminopotentidine and related compounds: a new class of ligands with high affinity and selectivity for the histamine H2 receptor. J.Med.Chem. 35 2231 PMID: 1613748
Ruat et al (1990) Reversible and irreversible labeling and autoradiographic localisation of the cerebral histamine H2 receptor using [125I]iodinated probes. Proc.Natl.Acad.Sci.USA 87 1658 PMID: 2308927
Xie et al (2006) Synthesis and pharmacological characterization of novel fluorescent histamine H2-receptor ligands derived from aminopotentidine. Bioorg.Med.Chem.Lett. 16 3886 PMID: 16730977
Keywords: Aminopotentidine, supplier, H2, antagonists, Receptors, Histamine, histaminergic, Histamine, H2, Receptors, Histamine, H2, Receptors, Tocris Bioscience
