BiologicalActivity
Broad-spectrumionchannelblocker;blockslateINa,ICa,IKrandIKsandincreasesQT.DisplaysclassIIIantiarrhythmicproperties.Alsoexhibitsfungicidalactivity;elicitsCa2+influxinSaccharomycescerevisiaeandcausesmitochondrialfragmentationandcelldeath.ThoughttostimulateautophagybytargetingupstreammTORC1controlpathways.SelectivelytoxictoNSCsinhESC-derivedcellpopulations.
CompoundLibraries
AmiodaronehydrochlorideisalsoofferedaspartoftheTocriscreenStemCellToolbox.FindoutmoreaboutcompoundlibrariesavailablefromTocris.
TechnicalData
| M.Wt | 681.77 |
| Formula | C25H29I2NO3.HCl |
| Storage | Storeat+4°C |
| Purity | ≥99%(HPLC) |
| CASNumber | 19774-82-4 |
| PubChemID | 29770 |
| InChIKey | ITPDYQOUSLNIHG-UHFFFAOYSA-N |
| Smiles | CCCCC2=C(C(C3=CC(I)=C(OCCN(CC)CC)C(I)=C3)=O)C1=CC=CC=C1O2.Cl |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 13.64 | 20 |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight681.77.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 1.47mL | 7.33mL | 14.67mL |
| 5mM | 0.29mL | 1.47mL | 2.93mL |
| 10mM | 0.15mL | 0.73mL | 1.47mL |
| 50mM | 0.03mL | 0.15mL | 0.29mL |
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ProductDatasheets
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