Biological Activity
High affinity dopamine D2 and 5-HT1A receptor partial agonist (Ki values are ~1.64 and 5.59 nM respectively). Also 5-HT2A antagonist (Ki = 8.7 nM). Suppresses morphine-induced emesis in vivo. Atypical antipsychotic.
Compound Libraries
Aripiprazole is also offered as part of the Tocriscreen Plus and Tocriscreen Library of FDA-Approved Compounds. Find out more about compound libraries available from Tocris.
Technical Data
| M. Wt | 448.39 |
| Formula | C23H27Cl2N3O2 |
| Storage | Store at -20°C |
| Purity | ≥99% (HPLC) |
| CAS Number | 129722-12-9 |
| PubChem ID | 60795 |
| InChI Key | CEUORZQYGODEFX-UHFFFAOYSA-N |
| Smiles | O=C2CCC1=CC=C(OCCCCN3CCN(C4=CC=CC(Cl)=C4Cl)CC3)C=C1N2 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 44.84 | 100 |
Preparing Stock Solutions
The following data is based on the product molecular weight 448.39. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.23 mL | 11.15 mL | 22.3 mL |
| 5 mM | 0.45 mL | 2.23 mL | 4.46 mL |
| 10 mM | 0.22 mL | 1.12 mL | 2.23 mL |
| 50 mM | 0.04 mL | 0.22 mL | 0.45 mL |
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Product Datasheets
References
References are publications that support the products' biological activity.
Davies et al (2004) Aripiprazole: a novel atypical antipsychotic drug with a uniquely robust pharmacology. CNS Drug Rev. 10 317 PMID: 15592581
Shiokawa et al (2007) Usefulness of the dopamine system-stabilizer aripiprazole for reducing morphine-induced emesis. Eur.J.Pharmacol. 570 108 PMID: 17678644
Keywords: Aripiprazole, supplier, high, affinity, dopamine, D2, 5-ht1a, 5-ht2a, partial, agonists, antagonists, antipsychotic, D2, Receptors, Tocris Bioscience
