Biological Activity
5-HT1A partial agonist and high affinity α1D adrenoceptor antagonist (Ki values are 2, 800 and 600 nM at cloned rat α1D, rat α1A and hamster α1B receptors respectively). Also available as part of the α1-Adrenoceptor Tocriset™.
Technical Data
| M. Wt | 458.42 |
| Formula | C22H31N3O3.2HCl |
| Storage | Store at RT |
| CAS Number | 21102-95-4 |
| PubChem ID | 24744861 |
| InChI Key | HZRPUQURUAXOHB-UHFFFAOYSA-N |
| Smiles | O=C1CC4(CCCC4)CC(N1CCN(CC3)CCN3C2=CC=CC=C2OC)=O.Cl.Cl |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solubility | Soluble to 100 mM in water |
Preparing Stock Solutions
The following data is based on the product molecular weight 458.42. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.18 mL | 10.91 mL | 21.81 mL |
| 5 mM | 0.44 mL | 2.18 mL | 4.36 mL |
| 10 mM | 0.22 mL | 1.09 mL | 2.18 mL |
| 50 mM | 0.04 mL | 0.22 mL | 0.44 mL |
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Product Datasheets
References
References are publications that support the products' biological activity.
Gruel and Glaser (1992) The putative 5-HT1A receptor antagonists NAN-190 and BMY 7378 are partial agonists in the rat dorsal raphe nucleus in vitro. Eur.J.Pharmacol. 211 211 PMID: 1535319
Piascik et al (1995) The specific contribution of the novel alpha-1D adrenoceptor to the contraction of vascular smooth muscle. J.Pharmacol.Exp.Ther. 275 1583 PMID: 8531132
Sharp et al (1990) Further investigation of the in vivo pharmacological properties of the putative 5-HT1A antagonist, BMY 7378. Eur.J.Pharmacol. 176 331 PMID: 1970304
Yang and Endoh (1997) Pharmacological evidence for β1D-adrenoceptors in the rabbit ventricular myocardium: analysis with BMY 7378. Br.J.Pharmacol 122 1541 PMID: 9422797
Keywords: BMY 7378 dihydrochloride, supplier, Selective, α1D-adrenoceptor, alpha1D-adrenoceptor, a1d-adrenoceptor, α1d-adrenergic, alpha1d-adrenergic, a1d-adrenergic, antagonist, 5-HT1A, partial, agonists, Receptors, Serotonin, BMY7378, dihydrochloride, Adrenergic, Alpha-1, Receptors, Tocris Bioscience
