Biological Activity
Potent and selective 5-HT1A receptor antagonist. Has partial agonist properties.
Technical Data
| M. Wt | 394.9 |
| Formula | C20H26N2O4.HCl |
| Storage | Store at RT |
| Purity | ≥98% (HPLC) |
| CAS Number | 102908-60-1 |
| PubChem ID | 56972149 |
| InChI Key | UEDYXFOPCMTXEH-UHFFFAOYSA-N |
| Smiles | Cl.O=C1CC2(CCCC2)CC(=O)N1CCNCC1COC2=C(O1)C=CC=C2 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solubility | Soluble to 25 mM in water |
Preparing Stock Solutions
The following data is based on the product molecular weight 394.9. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.53 mL | 12.66 mL | 25.32 mL |
| 5 mM | 0.51 mL | 2.53 mL | 5.06 mL |
| 10 mM | 0.25 mL | 1.27 mL | 2.53 mL |
| 50 mM | 0.05 mL | 0.25 mL | 0.51 mL |
Molarity Calculator
Reconstitution Calculator
The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.
Dilution Calculator
Product Datasheets
References
References are publications that support the products' biological activity.
Buisson Defferier and Van den Buuse (1992) Cardiovascular effects of the 5-HT1A receptor ligand, MDL 73005EF, in conscious hypertensive rats. Eur.J.Pharmacol. 223 133 PMID: 1362161
Gartside et al (1990) Effects of MDL 73005EF on central pre-and-postsynaptic 5HT1A receptor function in the rat in vivo. Eur.J.Pharmacol. 191 391 PMID: 1964908
Van der Hooff and Galvan (1991) Electrophysiology of the 5-HT1A ligand MDL 73005EF in the rat hippocampal slice. Eur.J.Pharmacol. 196 291 PMID: 1893914
Keywords: MDL 73005EF hydrochloride, supplier, Potent, selective, 5-HT1A, partial, agonists, Serotonin, Receptors, 5-HT1, MDL73005EF, hydrochloride, 5-HT1A, Receptors, Tocris Bioscience
