Biological Activity
Highly potent dopamine D2-like receptor antagonist; selective over D1-like receptors (Ki values are 0.1 and 740 nM for D2-like and D1-like receptors respectively). Also potent 5-HT1A receptor agonist (IC50 = 34 nM) and has affinity for sigma receptors.
Compound Libraries
Nemonapride is also offered as part of the Tocriscreen Plus. Find out more about compound libraries available from Tocris.
Technical Data
| M. Wt | 387.91 |
| Formula | C21H26ClN3O2 |
| Storage | Store at RT |
| Purity | ≥99% (HPLC) |
| CAS Number | 75272-39-8 |
| PubChem ID | 76968489 |
| InChI Key | QCYCDKUNJFKYEI-ZVWWNKPMSA-N |
| Smiles | O=C(C3=C(OC)C=C(NC)C(Cl)=C3)N[C@@H]1CCN(CC2=CC=CC=C2)[C@@H]1C.O=C(C6=C(OC)C=C(NC)C(Cl)=C6)N[C@H]4CCN(CC5=CC=CC=C5)[C@H]4C |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 9.7 | 25 | |
| ethanol | 7.76 | 20 |
Preparing Stock Solutions
The following data is based on the product molecular weight 387.91. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.58 mL | 12.89 mL | 25.78 mL |
| 5 mM | 0.52 mL | 2.58 mL | 5.16 mL |
| 10 mM | 0.26 mL | 1.29 mL | 2.58 mL |
| 50 mM | 0.05 mL | 0.26 mL | 0.52 mL |
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Product Datasheets
References
References are publications that support the products' biological activity.
Assie et al (1997) 5-HT1A receptor agonist properties of the antipsychotic, nemonapride: comparison with bromerguride and clozapine. Eur.J.Pharmacol. 334 141 PMID: 9369342
Terai et al (1983) Selective binding of YM-09151-2, a new potent neuroleptic, to D2-dopaminergic receptors. Jpn.J.Pharmacol. 33 749 PMID: 6138453
Ujike et al (1996) [3H]YM-09151-2 (nemonapride), a potent radioligand for both sigma1 and sigma2 receptor subtypes. Neuroreport 7 1057 PMID: 8804051
Keywords: Nemonapride, supplier, 5-HT1A, agonists, potent, D2-like, dopamine, antagonists, Serotonin, Receptors, Non-Selective, dopaminergic, YM09151, YM09151-2, YM, 09151, YM, 09151-2, Non-selective, Dopamine, Tocris Bioscience
