Biological Activity
Highly potent selective 5-HT1A receptor full agonist (pKi values are 9.0, 6.6, 7.5, 6.6 and < 6.0 for 5-HT1A, 5-HT1B, 5-HT1C, 5-HT2 and 5-HT3 receptors respectively). Possibly binds between the agonist binding site and the G protein interaction switch site, affecting the activation mechanism, and may display positive cooperativity. Anxiolytic following central administration in vivo.
Compound Libraries
S 14506 hydrochloride is also offered as part of the Tocriscreen Plus. Find out more about compound libraries available from Tocris.
Technical Data
| M. Wt | 443.94 |
| Formula | C24H26FN3O2.HCl |
| Storage | Desiccate at RT |
| Purity | ≥99% (HPLC) |
| CAS Number | 286369-38-8 |
| PubChem ID | 131905 |
| InChI Key | HWLZKPKZVOLFGK-UHFFFAOYSA-N |
| Smiles | Cl.COC1=CC2=C(C=CC=C2C=C1)N1CCN(CCNC(=O)C2=CC=C(F)C=C2)CC1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 40.75 | 100 | |
| ethanol | 4.07 | 10 |
Preparing Stock Solutions
The following data is based on the product molecular weight 443.94. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.25 mL | 11.26 mL | 22.53 mL |
| 5 mM | 0.45 mL | 2.25 mL | 4.51 mL |
| 10 mM | 0.23 mL | 1.13 mL | 2.25 mL |
| 50 mM | 0.05 mL | 0.23 mL | 0.45 mL |
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Product Datasheets
References
References are publications that support the products' biological activity.
Lima et al (1997) Atypical in vitro and in vivo binding of [3H]S-14506 to brain 5-HT1A receptors. J.Neural Transm. 104 1059 PMID: 9503258
Milligan et al (2001) S 14506: novel receptor coupling at 5-HT1A receptors. Neuropharmacology 40 334 PMID: 11166326
Colpaert et al (1992) S 14506: a novel, potent, high-efficacy 5-HT1A agonist and potential anxiolytic agent. Drug Dev.Res. 26 21 PMID:
Keywords: S 14506 hydrochloride, supplier, potent, 5-HT1A, agonists, Serotonin, Receptors, S14506, hydrochloride, 5-HT1A, Receptors, Tocris Bioscience
