Biological Activity
5-HT1A antagonist.
Technical Data
M. Wt | 474.4 |
Formula | C23H27N3O3.HBr |
Storage | Store at RT |
Purity | ≥98% (HPLC) |
CAS Number | 115338-32-4 |
PubChem ID | 107966 |
InChI Key | AXRUEPFPTQYHQD-UHFFFAOYSA-N |
Smiles | Br.COC1=C(C=CC=C1)N1CCN(CCCCN2C(=O)C3=CC=CC=C3C2=O)CC1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
Solvent | Max Conc. mg/mL | Max Conc. mM | |
---|---|---|---|
Solubility | |||
DMSO | 4.74 | 10 |
Preparing Stock Solutions
The following data is based on the product molecular weight 474.4. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 2.11 mL | 10.54 mL | 21.08 mL |
5 mM | 0.42 mL | 2.11 mL | 4.22 mL |
10 mM | 0.21 mL | 1.05 mL | 2.11 mL |
50 mM | 0.04 mL | 0.21 mL | 0.42 mL |
Molarity Calculator
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Product Datasheets
References
References are publications that support the products' biological activity.
Douris (1992) Effects of the putative 5-HT1A receptor antagonist NAN-190 on free feeding and on feeding induced by the 5-HT1A receptor agonist 8-OH-DPAT in the rat. Eur.J.Pharmacol. 219 105 PMID: 1397037
Glennon et al (1988) Arylpiperazine derivatives as high affinity 5-HT1A serotonin ligands. J.Med.Chem. 31 1968 PMID: 3172131
Williams and Glennon (1988) NAN-190: an arylpiperazine analog that antagonizes the stimulus effects of the 5-HT1A agonist 8-hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT). Eur.J.Pharmacol. 154 339 PMID: 2976673
Keywords: NAN-190 hydrobromide, supplier, 5-HT1A, antagonists, Serotonin, Receptors, 5-HT1, NAN190, 5-HT1A, Receptors, Tocris Bioscience