Biological Activity
Selective S1P2 allosteric agonist (EC50 = 0.48 μM). Selective for S1P2 receptors over a panel of 29 other receptors and transporters.
Compound Libraries
CYM 5520 is also offered as part of the Tocriscreen Plus. Find out more about compound libraries available from Tocris.
Technical Data
M. Wt | 345.39 |
Formula | C21H19N3O2 |
Storage | Store at +4°C |
Purity | ≥99% (HPLC) |
CAS Number | 1449747-00-5 |
PubChem ID | 25110470 |
InChI Key | FMYGNANMYYHBSU-UHFFFAOYSA-N |
Smiles | CC1=C(C(CN3C=C(C#N)C=CC3=O)=O)C=C(C)N1CC2=CC=CC=C2 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
Solvent | Max Conc. mg/mL | Max Conc. mM | |
---|---|---|---|
Solubility | |||
DMSO | 34.54 | 100 |
Preparing Stock Solutions
The following data is based on the product molecular weight 345.39. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 2.9 mL | 14.48 mL | 28.95 mL |
5 mM | 0.58 mL | 2.9 mL | 5.79 mL |
10 mM | 0.29 mL | 1.45 mL | 2.9 mL |
50 mM | 0.06 mL | 0.29 mL | 0.58 mL |
Molarity Calculator
Reconstitution Calculator
The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.
Dilution Calculator
Product Datasheets
References
References are publications that support the products' biological activity.
Satsu et al (2013) A sphingosine 1-phosphate receptor 2 selective allosteric agonist. Bioorg.Med.Chem. 21 5373 PMID: 23849205
Keywords: CYM 5520, supplier, selective, allosteric, agonists, sphingosine-1-phosphate, receptor, 2, S1P2, S1PR2, agonism, CYM5520, Sphingosine-1-phosphate, Receptors, Tocris Bioscience