Biological Activity
Selective 5-HT2 receptor agonist (Ki values are 0.44, 59, 69, 831 and 3700 nM for 5-HT2H, 5-HT2L, 5-HT2C, 5-HT1B and 5-HT1A receptors respectively). Hallucinogenic.
Technical Data
| M. Wt | 310.62 |
| Formula | C11H16BrNO2.HCl |
| Storage | Store at RT |
| Purity | ≥99% (HPLC) |
| CAS Number | 29705-96-2 |
| PubChem ID | 12626562 |
| InChI Key | SPBBKPOIDQIWDZ-UHFFFAOYSA-N |
| Smiles | BrC1=C(OC)C=C(CC(C)N)C(OC)=C1.Cl |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 31.06 | 100 |
Preparing Stock Solutions
The following data is based on the product molecular weight 310.62. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.22 mL | 16.1 mL | 32.19 mL |
| 5 mM | 0.64 mL | 3.22 mL | 6.44 mL |
| 10 mM | 0.32 mL | 1.61 mL | 3.22 mL |
| 50 mM | 0.06 mL | 0.32 mL | 0.64 mL |
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Product Datasheets
References
References are publications that support the products' biological activity.
Titiler et al (1987) Selectivity of serotonergic drugs for multiple brain serotonin receptors. Biochem.Pharmacol. 36 3265 PMID: 3663239
Arvanov et al (1999) A pre- and postsynaptic modulatory action of 5-HT and the 5-HT2A,2C receptor agonist DOB on NMDA-evoked responses in the rat medial prefrontal cortex. Eur.J.Neurosci. 11 2917 PMID: 10457188
McKenna et al (1989) Differentiation of 5-hydroxytryptamine2 receptor subtypes using 125I-R-(-)2,5-dimethoxy-4-iodo-phenylisopropylamine and 3H-ketanserin. J.Neurosci. 10 3482 PMID:
Keywords: DOB hydrochloride, supplier, Selective, 5-HT2, agonists, Non-Selective, Serotonin, Receptors, 2,5-Dimethoxy-4-bromoamphetamine, hydrochloride, Non-selective, 5-HT2, Tocris Bioscience
