Biological Activity
A major metabolite of clozapine; a potent and selective 5-HT2C serotonin receptor antagonist.
Technical Data
| M. Wt | 312.8 |
| Formula | C17H17ClN4 |
| Storage | Store at RT |
| Purity | ≥99% (HPLC) |
| CAS Number | 6104-71-8 |
| PubChem ID | 210172 |
| InChI Key | NIBOMXUDFLRHRV-UHFFFAOYSA-N |
| Smiles | ClC1=CC=C2NC3=C(C=CC=C3)C(=NC2=C1)N1CCNCC1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 31.28 | 100 | |
| ethanol | 31.28 | 100 |
Preparing Stock Solutions
The following data is based on the product molecular weight 312.8. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.2 mL | 15.98 mL | 31.97 mL |
| 5 mM | 0.64 mL | 3.2 mL | 6.39 mL |
| 10 mM | 0.32 mL | 1.6 mL | 3.2 mL |
| 50 mM | 0.06 mL | 0.32 mL | 0.64 mL |
Molarity Calculator
Reconstitution Calculator
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Product Datasheets
References
References are publications that support the products' biological activity.
Fox and Brotchie (1996) Normethylclozapine potentiates the action of quinpirole in the 6-hydroxydopamine lesioned rat. Eur.J.Pharmacol. 301 27 PMID: 8773443
Kuoppamäki et al (1993) Clozapine and methylclozapine are potent 5-HT1C receptor antagonists. Eur.J.Pharmacol. 245 179 PMID: 8387927
Wong et al (1996) Effects of clozapine metabolites and chronic clozapine treatment on rat brain GABAA receptors. Eur.J.Pharmacol. 314 319 PMID: 8957253
Keywords: N-Desmethylclozapine, supplier, 5-HT2C, antagonists, Serotonin, Receptors, Norclozapine, Normethylclozapine, Norclozapine, 5-HT2C, Receptors, Tocris Bioscience
