Biological Activity
Non-selective opioid receptor antagonist (Ki values are 0.017, 0.072 and 0.23 nM for κ-, μ- and δ-opioid receptors).
Technical Data
| M. Wt | 425.56 |
| Formula | C26H35NO4 |
| Storage | Store at RT |
| Purity | ≥99% (HPLC) |
| CAS Number | 14357-78-9 |
| PubChem ID | 443408 |
| InChI Key | OIJXLIIMXHRJJH-KNLIIKEYSA-N |
| Smiles | OC1=CC=C3C2=C1O[C@@H]([C@]7(OC)[C@@H]([C@@](C)(O)C)C4)[C@]52[C@@]4(CC7)[C@H](N(CC6CC6)CC5)C3 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 8.51 | 20 | |
| ethanol | 10.64 | 25 |
Preparing Stock Solutions
The following data is based on the product molecular weight 425.56. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.35 mL | 11.75 mL | 23.5 mL |
| 5 mM | 0.47 mL | 2.35 mL | 4.7 mL |
| 10 mM | 0.23 mL | 1.17 mL | 2.35 mL |
| 50 mM | 0.05 mL | 0.23 mL | 0.47 mL |
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Product Datasheets
References
References are publications that support the products' biological activity.
Paterson et al (1983) Classification of opioid receptors. Br.Med.Bull. 39 31 PMID: 6301606
Raynor et al (1994) Pharmacological characterization of the cloned κ-, δ-, and μ-opioid receptors. Mol.Pharmacol. 45 330 PMID: 8114680
Iwasaki et al (1994) The effect of the nonselective opioid antagonist diprenorphine vasopressin secretion in the rat. Endocrinology 134 48 PMID: 8275962
Keywords: Diprenorphine, supplier, Non-Selective, opioids, antagonists, Receptors, Miscellaneous/Non-selective, Opioids, Tocris Bioscience
