Biological Activity
5-HT1 and 5-HT2C receptor partial agonist (Ki values are 40, 52 and 81 nM for 5-HT1A, 5-HT1B and 5-HT2C receptors respectively). Reduces 5-HIAA levels in the striatum and exhibits antiaggressive behavior in vivo.
Technical Data
| M. Wt | 256.73 |
| Formula | C12H16N2O2.HCl |
| Storage | Store at RT |
| Purity | ≥98% (HPLC) |
| CAS Number | 98206-09-8 |
| PubChem ID | 3025067 |
| InChI Key | JFSOSUNPIXJCIX-UHFFFAOYSA-N |
| Smiles | Cl.C1CN(CCN1)C1=C2OCCOC2=CC=C1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| phosphate buffered saline | 25.67 | 100 | |
| water | 25.67 | 100 |
Preparing Stock Solutions
The following data is based on the product molecular weight 256.73. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.9 mL | 19.48 mL | 38.95 mL |
| 5 mM | 0.78 mL | 3.9 mL | 7.79 mL |
| 10 mM | 0.39 mL | 1.95 mL | 3.9 mL |
| 50 mM | 0.08 mL | 0.39 mL | 0.78 mL |
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References
References are publications that support the products' biological activity.
Gommans et al (1997) Discriminative stimulus properties of eltoprazine. Life Sci. 61 11 PMID: 9200664
Miczek et al (1989) Brain 5-HT and inhibition of aggressive behavior in animals: 5-HIAA and receptor subtypes. Psychopharmacol.Bull. 25 399 PMID: 2483273
Schipper et al (1990) Neurochemical profile of eltoprazine. Drug Metabol.Drug Interact. 8 85 PMID: 1982626
Keywords: Eltoprazine hydrochloride, supplier, 5-HT2C, receptor, partial, agonists, 5-HT1, Serotonin, Receptors, 5-HT1B, Receptors, Tocris Bioscience
