Biological Activity
A highly potent cannabinoid receptor agonist (Ki values are 0.061 and 0.52 nM at cloned human CB1 and CB2 receptors respectively). Induces spatial memory deficits and suppresses hippocampal firing rates in rats. Also displays agonist activity at GPR55 (EC50 = 26 nM).
Technical Data
| M. Wt | 386.57 |
| Formula | C25H38O3 |
| Storage | Store at -20°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 112830-95-2 |
| PubChem ID | 9821569 |
| InChI Key | SSQJFGMEZBFMNV-WOJBJXKFSA-N |
| Smiles | CCCCCCC(C)(C)C1=CC(O)=C([C@@]2([H])[C@@](C(C)(C)O3)([H])CC=C(CO)C2)C3=C1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 38.66 | 100 | |
| ethanol | 38.66 | 100 |
Preparing Stock Solutions
The following data is based on the product molecular weight 386.57. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.59 mL | 12.93 mL | 25.87 mL |
| 5 mM | 0.52 mL | 2.59 mL | 5.17 mL |
| 10 mM | 0.26 mL | 1.29 mL | 2.59 mL |
| 50 mM | 0.05 mL | 0.26 mL | 0.52 mL |
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Product Datasheets
References
References are publications that support the products' biological activity.
Howlett et al (1990) Stereochemical effects of 11-OH-Δ8-tetrahydrocannabinol-dimethylheptyl to inhibit adenylate cyclase and bind to the cannabinoid receptor. Neuropharmacology 29 161 PMID: 2158635
Mechoulam et al (1988) Enantiomeric cannabinoids: stereospecificity of psychotropic activity. Experientia 44 762 PMID: 3416993
Robinson et al (2007) The synthetic cannabinoid HU210 reduces spatial memory deficits and suppresses hippocampal firing rates in rats. Br.J.Pharmacol. 151 688 PMID: 17502849
Ryberg et al (2007) The orphan receptor GPR55 is a novel cannabinoid receptor. Br.J.Pharmacol. 152 1092 PMID: 17876302
Keywords: HU 210, supplier, potent, cannabinoids, agonists, Non-Selective, Receptors, HU210, cb2r, cb1r, Non-selective, Cannabinoids, Tocris Bioscience
