Biological Activity
Ligand at the GABAA receptor benzodiazepine modulatory site. Anxiolytic, anticonvulsant and sedative/hypnotic agent.
Technical Data
| M. Wt | 321.16 |
| Formula | C15H10Cl2N2O2 |
| Storage | Store at RT |
| CAS Number | 846-49-1 |
| PubChem ID | 3958 |
| InChI Key | DIWRORZWFLOCLC-UHFFFAOYSA-N |
| Smiles | O=C2C(O)N=C(C3=CC=CC=C3Cl)C1=CC(Cl)=CC=C1N2 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 32.12 | 100 | |
| ethanol | 12.85 | 40 |
Preparing Stock Solutions
The following data is based on the product molecular weight 321.16. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.11 mL | 15.57 mL | 31.14 mL |
| 5 mM | 0.62 mL | 3.11 mL | 6.23 mL |
| 10 mM | 0.31 mL | 1.56 mL | 3.11 mL |
| 50 mM | 0.06 mL | 0.31 mL | 0.62 mL |
Molarity Calculator
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Product Datasheets
References
References are publications that support the products' biological activity.
Bonavita et al (2002) Tolerance to the sedative effect of lorazepam correlates with a diminution in cortical release and affinity for glutamate. Neuropharmacol. 42 619 PMID:
Keywords: Lorazepam, supplier, Acts, benzodiazepine, modulatory, site, GABAA, Receptors, GABAA, Receptors, Tocris Bioscience
