Biological Activity
Dopamine uptake inhibitor (IC50 = 4 μM). Increases extracellular dopamine (DA) levels in the nucleus accumbens and substitutes for cocaine in discrimination tests in mice.
Technical Data
| M. Wt | 273.35 |
| Formula | C15H15NO2S |
| Storage | Store at +4°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 112111-43-0 |
| PubChem ID | 9690109 |
| InChI Key | YFGHCGITMMYXAQ-LJQANCHMSA-N |
| Smiles | O=[S@](CC(N)=O)C(C1=CC=CC=C1)C2=CC=CC=C2 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 27.34 | 100 | |
| ethanol | 5.47 | 20 |
Preparing Stock Solutions
The following data is based on the product molecular weight 273.35. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.66 mL | 18.29 mL | 36.58 mL |
| 5 mM | 0.73 mL | 3.66 mL | 7.32 mL |
| 10 mM | 0.37 mL | 1.83 mL | 3.66 mL |
| 50 mM | 0.07 mL | 0.37 mL | 0.73 mL |
Molarity Calculator
Reconstitution Calculator
The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.
Dilution Calculator
Product Datasheets
References
References are publications that support the products' biological activity.
Loland et al (2012) R-modafinil (armodafinil): a unique dopamine uptake inhibitor and potential medication for psychostimulant abuse. Biol.Psychiatry 72 405 PMID: 2537794
Keywords: (R)-Modafinil, supplier, dopamine, transporters, reuptake, inhibitors, inhibits, DAT, R-enantiomer, cocaine, discrimination, armodafinil, Dopamine, Transporters, Tocris Bioscience
