Biological Activity
High affinity, water-soluble CB1/CB2 receptor agonist (Ki values are 1.5 and 0.32 nM for CB1 and CB2 receptors respectively). Active in vivo following i.v. and i.c.v. administration.
Licensing Information
Sold under license from VCU-IPF
Technical Data
| M. Wt | 445.04 |
| Formula | C26H36N2O2.HCl |
| Storage | Store at -20°C |
| Purity | ≥99% (HPLC) |
| CAS Number | 874745-43-4 |
| PubChem ID | 24848973 |
| InChI Key | LSHUCXYFAOTXLT-MUCZFFFMSA-N |
| Smiles | OC1=CC(C(C)(C)CCCCN4C=CN=C4)=CC3=[C@@]1[C@H]2[C@H]([C@@](C)(C)O3)CC=C(C)C2.Cl |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| ethanol | 44.5 | 100 | |
| water | 8.9 | 20mM with gentle warming |
Preparing Stock Solutions
The following data is based on the product molecular weight 445.04. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.25 mL | 11.23 mL | 22.47 mL |
| 5 mM | 0.45 mL | 2.25 mL | 4.49 mL |
| 10 mM | 0.22 mL | 1.12 mL | 2.25 mL |
| 50 mM | 0.04 mL | 0.22 mL | 0.45 mL |
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Product Datasheets
References
References are publications that support the products' biological activity.
Martin et al (2006) Pharmacological characterization of novel water-soluble cannabinoids. J.Pharmacol.Exp.Ther. 318 1230 PMID: 16757541
Keywords: O-2545 hydrochloride, supplier, High, affinity, water-soluble, CB1/CB2, agonists, Non-Selective, cannabinoids, Receptors, cb2r, cb1r, Non-selective, Cannabinoids, Tocris Bioscience
