Biological Activity
Anticonvulsant and antiepileptic; also used to treat neuropathic pain. Binds with high affinity and selectivity to the α2δ subunit of voltage-sensitive Ca2+ channels and modulates their activity. Displays anxiolytic-like activity in ethological and conflict models of anxiety. Analog of GABA (Cat. No. 0344).
Licensing Information
Sold for research purposes under agreement from Pfizer Inc.
Technical Data
| M. Wt | 159.23 |
| Formula | C8H17NO2 |
| Storage | Store at RT |
| CAS Number | 148553-50-8 |
| PubChem ID | 5486971 |
| InChI Key | AYXYPKUFHZROOJ-ZETCQYMHSA-N |
| Smiles | CC(C)C[C@H](CN)CC(O)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 15.92 | 100 |
Preparing Stock Solutions
The following data is based on the product molecular weight 159.23. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 6.28 mL | 31.4 mL | 62.8 mL |
| 5 mM | 1.26 mL | 6.28 mL | 12.56 mL |
| 10 mM | 0.63 mL | 3.14 mL | 6.28 mL |
| 50 mM | 0.13 mL | 0.63 mL | 1.26 mL |
Molarity Calculator
Reconstitution Calculator
The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.
Dilution Calculator
Product Datasheets
References
References are publications that support the products' biological activity.
Field et al (2001) Pregabalin may represent a novel class of anxiolytic agents with a broad spectrum of activity. Br.J.Pharmacol. 132 1 PMID: 11156553
Kumar et al (2010) Evidence that pregabalin reduces neuropathic pain by inhibiting the spinal release of glutamate. J.Neurochem. 113 552 PMID: 20132471
Arain (2009) Pregabalin in the management of partial epilepsy. Neuropsych.Dis.Treat. 5 407 PMID:
Keywords: Pregabalin, supplier, anticonvulsants, neuropathic, pain, GABA, analgesics, anxiolytics, a2d, alpha2delta, α2δ, voltage-sensitive, calcium, channels, Ca2+, Voltage-gated, Calcium, Channels, Tocris Bioscience
