Biological Activity
Prototypical σ1 receptor agonist. Behaviorally active in animal models of memory and stress.
Technical Data
M. Wt | 293.84 |
Formula | C17H23NO.HCl |
Storage | Desiccate at +4°C |
Purity | ≥98% (HPLC) |
CAS Number | 133005-41-1 |
PubChem ID | 16759596 |
InChI Key | CFMYXEVWODSLAX-CKYAAQHSSA-N |
Smiles | OC1=CC=C2C([C@@](CC3)(C)[C@H](C)[C@@H](N3CC=C)C2)=C1.Cl |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
Solvent | Max Conc. mg/mL | Max Conc. mM | |
---|---|---|---|
Solubility | |||
DMSO | 29.38 | 100 | |
water | 29.38 | 100 |
Preparing Stock Solutions
The following data is based on the product molecular weight 293.84. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 3.4 mL | 17.02 mL | 34.03 mL |
5 mM | 0.68 mL | 3.4 mL | 6.81 mL |
10 mM | 0.34 mL | 1.7 mL | 3.4 mL |
50 mM | 0.07 mL | 0.34 mL | 0.68 mL |
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References
References are publications that support the products' biological activity.
Kamei et al (1996) (+)-SKF-10,047 and dextromethorphan ameliorate conditioned fear stress via dopaminergic systems linked to phenytoin-regulated σ1 sites. Eur.J.Pharmacol. 309 149 PMID: 8874133
Matsuno et al (1995) Involvement of σ1 receptor in (+)-N-allylnormetazocine-stimulated hippocampal cholinergic functions in rats. Brain Res. 690 200 PMID: 8535837
Walker et al (1990) Sigma receptors: biology and function. Pharmacol.Rev. 42 355 PMID: 1964225
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