Biological Activity
5-HT and noradrenalin re-uptake inhibitor (SNRI). Produces weight loss in rats via inhibition of food intake and increased energy expenditure. Antidepressant.
Technical Data
| M. Wt | 316.31 |
| Formula | C17H26NCl.HCl |
| Storage | Store at RT |
| Purity | ≥99% (HPLC) |
| CAS Number | 84485-00-7 |
| PubChem ID | 64764 |
| InChI Key | UWAOJIWUVCMBAZ-UHFFFAOYSA-N |
| Smiles | ClC1=CC=C(C2(CCC2)C(CC(C)C)N(C)C)C=C1.Cl |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 31.63 | 100 | |
| water | 1.58 | 5 |
Preparing Stock Solutions
The following data is based on the product molecular weight 316.31. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.16 mL | 15.81 mL | 31.61 mL |
| 5 mM | 0.63 mL | 3.16 mL | 6.32 mL |
| 10 mM | 0.32 mL | 1.58 mL | 3.16 mL |
| 50 mM | 0.06 mL | 0.32 mL | 0.63 mL |
Molarity Calculator
Reconstitution Calculator
The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.
Dilution Calculator
Product Datasheets
References
References are publications that support the products' biological activity.
Jackson et al (1997) Comparison of the effects of sibutramine and other monoamine reuptake inhibitors on food intake in the rat. Br.J.Pharmacol. 121 1758 PMID: 9283714
Gundlah et al (1997) In vivo criteria to differentiate monoamine reuptake inhibitors from releasing agents: sibutramine is a reuptake inhibitor. J.Pharmacol.Exp.Ther. 283 581 PMID: 9353373
Buckett et al (1988) The pharmacology of sibutramine hydrochloride (BTS 54524), a new antidepressant which induces rapid noradrenergic down-regulation. Prog.Neuro-Psychopharm.Biol.Psychiat. 12 575 PMID:
Keywords: Sibutramine hydrochloride, supplier, 5-HT, noradrenalin, reuptake, inhibitors, inhibits, SNRI, Noradrenalin, Transporter, NET, Adrenergic, Transporters, Monoamine, Neurotransmitter, Serotonin, SERT, 5-Hydroxytryptamine, BTS54524, noradrenaline, BTS, 54-524, 5-HT, Transporters, Tocris Bioscience
