BiologicalActivity
PhotoswitchableKvchannelblocker(IC50valuesare2and64μMat500nmand380nmrespectively).Switchesconformationfromcistotransat500nmandtranstocisat380nm.ExhibitsminimalactivityatNav1.2andL-typeCa2+channels.Stimulatesactionpotentialfiringofhippocampalneuronsinvitroat500nmandrestoresvisualresponsivenessinblindmiceat380nm.
LicensingInformation
SoldunderlicensefromPhotoswitchBiosciences,Inc.
TechnicalData
| M.Wt | 443.97 |
| Formula | C23H30ClN5O2 |
| Storage | Storeat-20°C |
| Purity | ≥98%(HPLC) |
| PubChemID | 91826090 |
| InChIKey | CTVKLIGDHHKPIB-UHFFFAOYSA-N |
| Smiles | O=C(C=C)NC(C=C2)=CC=C2/N=N/C1=CC=C(NC(C[N+](CC)(CC)CC)=O)C=C1.[Cl-] |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 8.88 | 20 |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight443.97.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 2.25mL | 11.26mL | 22.52mL |
| 5mM | 0.45mL | 2.25mL | 4.5mL |
| 10mM | 0.23mL | 1.13mL | 2.25mL |
| 50mM | 0.05mL | 0.23mL | 0.45mL |
MolarityCalculator
ReconstitutionCalculator
Thereconstitutioncalculatorallowsyoutoquicklycalculatethevolumeofareagenttoreconstituteyourvial.Simplyenterthemassofreagentandthetargetconcentrationandthecalculatorwilldeterminetherest.